Sphingolipid lysosomal storage diseases: from bench to bedside

Abstract Johann Ludwig Wilhelm Thudicum described sphingolipids (SLs) in the late nineteenth century, but it was only in the past fifty years that SL research surged in importance and applicability.Currently, sphingolipids and their metabolism are hotly Decorative Art debated topics in various biochemical fields.Similar to other macromolecular reac

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Integrating HEC-RAS, GIS, and LISREL for assessing and enhancing urban building resilience against flood threats: Comprehensive model and analysis

Floods pose significant threats to urban areas, resulting in substantial human and financial losses annually.The vulnerability of key urban centers to these Oracle Cards risks diminishes their efficiency, leading to public dissatisfaction and service deficiencies.Recognizing and enhancing the resilience of essential buildings becomes crucial in mit

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Near-Field IR Orientational Spectroscopy of Silk

Orientational dependence of the IR absorbing amide bands of silk is demonstrated from two orthogonal longitudinal Multi-Process welders and transverse microtome slices with a thickness of only ∼100 nm.Scanning near-field optical microscopy (SNOM) which preferentially probes orientation perpendicular to the sample’s surface was used.Spat

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Modulation of the Unfolded Protein Response Is the Core of MicroRNA-122-Involved Sensitivity to Chemotherapy in Hepatocellular Carcinoma

The loss of microRNA-122 (miR-122) expression correlates to many characteristic properties of hepatocellular carcinoma (HCC) cells, including clonogenic survival, anchorage-independent growth, migration, invasion, epithelial-mesenchymal transition, and tumorigenesis.However, all of these findings do not sufficiently explain the oncogenic potential

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A multi-omics approach to unravelling the coupling mechanism of nitrogen metabolism and phenanthrene biodegradation in soil amended with biochar

The presence of polycyclic aromatic hydrocarbons (PAHs) in soil negatively affects the environment and the degradation of these contaminants is influenced by Insurance nitrogen metabolism.However, the mechanisms underlying the interrelationships between the functional genes involved in nitrogen metabolism and phenanthrene (PHE) biodegradation, as w

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